WELCOME !

Our research program is generally focused in four different areas of transport phenomena and tissue remodeling in both the cardiovascular and pulmonary systems and include:

1) nitric oxide metabolism, production, and elimination in the lungs, 2) wound healing and tissue remodeling in the lungs, 3) pre-vascularization of implantable thick tissues, and 4) 3-D microtissues perfused with human capillaries in a high throughput design (newly funded by an NIH "Challenge Grant" from the NIEHS).

We utilize both experimental and theoretical techniques. The projects involving prevascularization of an implantable tissue and the creation of perfused 3-D human microtissues are multidiscilplinary and involve resources at the Edwards Lifesciences Center for Cardiovascular Technology, active collaborations with Dr. Chris Hughes and Dr. Abe Lee, and use of the Integrated Nanosystems Research Facility. Much of the experimental work in exhaled nitric oxide is carried out the Institute of Clinical and Translational Science here at UCI which offers full nursing support as well as other services including exercise-testing and statistical support. The wound-healing and tissue engineering projects are supported by a fully-equipped modern cell and tissue culture lab, and focuses on the non-invasive (optical) assessment or characterization of micro- and macromechanial properties of tissues. An additional key collaboration is with the Beckman Laser Institute (via Dr. Bruce Tromberg) and their world-class optical imaging faciltities including multi-photon microscopy and optical coherence tomography. We invite you to explore the lab in more details including specific research projects and the quality individuals that make up the lab.

Steve George (PI)